25. September 2014
acib GmbH, Graz Austria

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acib – Innovations from Nature

The Austrian Centre of Industrial Biotechnology (acib) is an international Research Centre for Industrial Biotechnology with locations in Vienna, Graz, Innsbruck, Tulln (A), Hamburg, Bielefeld (D), Pavia (I) and Barcelona (E). Using the concepts of nature, acib-scientists replace traditional industrial methods with new, more economic and ecological technologies. At acib, 200+ scientific employees work in more than 40 research projects.

As a research center of excellence, acib is an international partnership of currently 80+ international universities and industry partners, including renowned companies such as BASF, DSM, Sandoz, Boehringer Ingelheim, Jungbunzlauer, F. Hoffmann-La Roche, Novartis, VTU Technology or Sigma Aldrich. Owners are the Universities of Innsbruck and Graz, Graz University of Technology, the University of Natural Resources, Vienna and Joanneum Research.

Research Fields:

The acib research fields provide the scientific and structural basis for cross disciplinary research involving key disciplines such as organic chemistry, microbiology, molecular, structural and cell biology, bioinformatics, modelling and simulation, process engineering, and systems biotechnology.

Biocatalytic Synthesis

Biocatalysis is key discipline in industrial biotechnology. It deals with the use of natural catalysts (enzymes) instead of the chemical catalysts being used in conventional chemistry. Reactions become easier, cheaper, more energy-saving and less harmful to the environment and dangerous waste can be avoided. 

Enzymes & Polymers

The aim of this research field is the development of mechanistic knowledge about the function of enzymes on polymers and novel tools for the modification of bio/synthetic polymers and the production of functional and intelligent polymeric materials.

Cell Design & Engineering

Modern cell design and engineering has to become more rational and integrate aspects of bioprocessing including up- and downstream processing. Predictable cellular performance and high yield production of proteins and biochemicals should become achievable using Systems Biotechnology derived knowledge. 

Protein Design & Engineering

In nature, proteins evolve to support organisms’ survival and propagation. For utilization outside their original habitat proteins need to be re- or de novo designed and adapted to non-natural conditions and application-specific requirements using protein engineering. Our team has broad expertise in the fields of molecular enzymology, structural biology and biotechnology.

Bioprocess Engineering

An emerging focus for the biotech-industry is to implement “Quality by Design” criteria in their production processes to further optimize economics. According to this concept the quality of a certain product arises from the detailed knowledge about the product itself and of its production process and the risks contained therein.

Metabolic Modelling

As the knowledge of genes, proteins and other biological components is accumulating strong interest has grown to study the interaction between these parts in order to understand complete biological systems. Here, the systems biology approach provides concepts and tools. The ultimate goal is to rebuild nature on the computer.

Synthetic Biology

By November 2011 the second ACIB junior group on Synthetic Biology has been established in Graz. The research focuses on non-canonical amino acids as building blocks for synthetic proteins and bioactive compounds. The non-canonical amino acids have unusual side-chains and can furnish proteins or bioactive compounds with desired traits.

Shaking Applications:

Bacteria, Fungi, Yeast, Mammalian Cells, Biocatalysis, Drinks...