16. September 2014
Gottfried Wilhelm Leibniz Universität Hannover, Hanover Germany

Watch Video

Number of people in group: 50

Shaking application: microbial, mammalian, yeast and microalgae cells


Research projects and goals

Bioprocess Engineering

Cultivation processes of bacteria, fungi and mammalian cell lines as well as enzymatic processes are the objectives of this research and development area. Processes for the production of antibiotics, various enzymes, nutritional ingredients, cytokines, antibodies and vaccines are currently under investigation.

Cell Culture Technology

The cultivation of mammalian cell lines has an increased importance in the research activities of the institute. It allows for the production of biologically active proteins (e.g. antibodies, cytokines, vaccines), for use in diagnostic and therapeutic applications. Interest is not only derived from the products but also the cells themselves. They can be utilized in gene therapies, pharma testing, and in the field of tissue engineering.

Tissue Engineering

Tissue engineering is a major field of investigation within the framework of the DFG-excellence cluster REBIRTH. Its aim is to treat tissue or organ defects through the use of artificially produced tissues. Adhered to suitable biomatrices, cells are grown into functionalized tissues under controlled and reproducible conditions.

Downstream Processing

Downstream Processing remains one of the most cost decisive factors in biotechnological production. The adaption of the latest techniques and alternative materials is a major focus of this research area. Filtration, extraction, chromatography and membrane adsorption are available at the institute and can be applied to industrial processes ranging from laboratory to production scale.

Protein Chemistry

The biological activity of proteins depends on their structural confirmation. For the production of biologically active proteins the correct folding and their preservation over the course of downstream processing is the utmost importance. Molecular, biological and proteochemical aspects of protein production of cytokines and vaccines are areas of further investigation.